DOTCHROME – DS

87
DOTCHROME-DS

DESCRIPTION:
Dotchrome-DS
contains Carbazochrome Salicylate. Carbazochrome Salicylate is Adrenochrome monosemicarbazone sodium salicylate complex. It is haemostatic compound used as a powerful systemic coagulant. It is used in therapy at-least from the last 4 Decades.

COMPOSITION:
Each ml. contains:

Carbazochrome Salicylate

eqv. to Adrenochrome Monosemicarbazone I.P 10mg.

Benzyl Alcohol I.P (As Preservative)                     2.5% w/v.

SAFETY OF DOTCHROME-DS:

The use of Dotchrome-DS as a haemostat has proven its safety in animals.

Dotchrome-DS does not have any effect on blood pressure, cardiac rate and output or blood clotting mechanism (USD. 1960).

Dotchrome-DS injection neither produces local reaction at the site nor systemic or metabolic disturbances.

Dotchrome-DS was thought as the compound involved in producing schizophrenia, but now this possibility is discontinued (Lewis. 1970).

Since the action of Dotchrome-DS is not mediated through blood component, it does not form emboli.

INDICATIONS:

Dotchrome-DS in indicated to control the external and internal bleeding due to various causes in large and small animals such as :

  • Gastrointestinal Bleeding

  • Epistaxis

  • Haemoptysis

  • Bleeding Ulcers

  • Antepartum & Post Partum Bleeding

  • Vaginal Bleeding

  • Haematuria

  • Haemorrhagic Cystitis

  • Cerebral Haemorrhage

  • Retinal Haemorrhage

  • Pulmonary Bleeding

  • Blood in Milk

  • In conditions associated with increased capillary permeability i.e. Allergic conditions

  • Inflammation.

DOSE & ROUTE OF ADMINISTRATION:

By I/M route only.

Large Animals: 2.5 – 5 ml

Small Animals: 1 – 1.5 ml

Or as directed by veterinarian.

PRESENTATION:
Vial of 30 ml.

For the use of a Veterinarian in a Hospital or in a Laboratory or in a Farm Only.

SCHEDULE ‘H’ PRESCRIPTION DRUG

REFERENCES:

  1. Jones L.M., Booth N. H. McDonald L. E. (1971) in Veterinary Pharmacology and Therapeutics Edn fourth lowa State Univ. Press P. 473.

  2. Lewis’s Pharmacology (1970) Edn fourth, E. S. Livingstone Edinburg and London P 370.

  3. Parrot J. L. (1949). Adrenochrome, Compt. Bend. Soc. biol 143 819-822

  4. Perrault M., Vignalou J., Poinsard G and Breiu A (1950). Soc. Med. Hop. 9-10, 408.

  5. The United States Dispensatory (1960) Edn 26th J.B, Lippincott Co., Philadelphia P-242.