PREGDOT is a synthetic prostaglandin containing CLOPROSTENOL SODIUM an analogue of PGF2∝ for use in cattle, buffalo, horses, sheep, goat, dogs and pigs. It is structurally related to prostaglandin F2∝.
CLOPROSTENOL is a functional analogue of prostaglandin F2∝ having a specific luteolytic action. It causes functional and morphological regression of corpus luteum in cattle, buffalo, horses, sheep & goats followed by return to oestrus and normal ovulation. Cloprostenol also has direct stimulating effect on uterine smooth muscle .
Role of PREGDOT in anoestrus:
It causes constriction of utero-ovarian blood vessels causing partial ischemia, starvation & death of luteal cells.
PREGDOT competes with LH for receptor site & prevents further progesterone production.
It inactivates the adenyl cyclase system to inhibit progesterone secretion and inactivates lysosomal enzymes to cause morphological regression of corpus luteum.
Each ml contains:
Cloprostenol sodium : 263 mcg
(eqv. to 250 mcg Cloprostenol)
COWS & BUFFALOES:
Termination of pathological pregnancy
Synchronization of oestrus
SHEEP, GOAT & SWINE:
Synchronization of estrous
Termination of pregnancy from mismating.
DOSE & ROUTE OF ADMINISTRATION:
By I.M Route Only.
CATTLE AND BUFFALOES:
2 ml (500 mcg)
0.5 – 1 ml for mares weighing up to 400 kg b.wt
1 – 2 ml for mares weighing more than 400 kg b.wt.
SHEEP AND GOAT:
0.5 ml (125 mcg)
0.7 ml (175 mcg) (for induction of parturition)
Vial of 2ml including Tray, Syringe & Mono-Carton.
SCHEDULE ‘H’ PRESCRIPTION DRUG