PREGDOT

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DESCRIPTION:

PREGDOT is a synthetic prostaglandin containing CLOPROSTENOL SODIUM an analogue of PGF2∝ for use in cattle, buffalo, horses, sheep, goat, dogs and pigs. It is structurally related to prostaglandin F2∝.

CLOPROSTENOL is a functional analogue of prostaglandin F2∝ having a specific luteolytic action. It causes functional and morphological regression of corpus luteum in cattle, buffalo, horses, sheep & goats followed by return to oestrus and normal ovulation. Cloprostenol also has direct stimulating effect on uterine smooth muscle .

Role of PREGDOT in anoestrus:

  • It causes constriction of utero-ovarian blood vessels causing partial ischemia, starvation & death of luteal cells.

  • PREGDOT competes with LH for receptor site & prevents further progesterone production.

  • It inactivates the adenyl cyclase system to inhibit progesterone secretion and inactivates lysosomal enzymes to cause morphological regression of corpus luteum.

COMPOSITION:

Each ml contains:

Cloprostenol sodium                :    263 mcg

(eqv. to 250 mcg Cloprostenol)

INDICATIONS:

COWS & BUFFALOES:

  • Luteal Cysts

  • Pyometra

  • Chronic Endometritis

  • Mummified foetus

  • Termination of pathological pregnancy

MARES:

  • Pseudopregnancy

  • Lactational anoestrus

  • Synchronization of oestrus

SHEEP, GOAT & SWINE:

  • Synchronization of estrous

CANINE:

  • Pyometra

  • Termination of pregnancy from mismating.

DOSE & ROUTE OF ADMINISTRATION:

By I.M Route Only.

CATTLE AND BUFFALOES:

2 ml (500 mcg)

HORSES:
0.5 – 1 ml for mares weighing up to 400 kg b.wt
1 – 2 ml for mares weighing more than 400 kg b.wt.

SHEEP AND GOAT:
0.5 ml (125 mcg)

PIG:
0.7 ml (175 mcg) (for induction of parturition)

PRESENTATION:

Vial of 2ml including Tray, Syringe & Mono-Carton.

SCHEDULE ‘H’ PRESCRIPTION DRUG