PREGDOT

Description

PREGDOT is a synthetic prostaglandin containing CLOPROSTENOL SODIUM an analogue of PGF2∝ for use in cattle, buffalo, horses, sheep, goat, dogs and pigs. It is structurally related to prostaglandin F2∝.

CLOPROSTENOL is a functional analogue of prostaglandin F2∝ having a specific luteolytic action. It causes functional and morphological regression of corpus luteum in cattle, buffalo, horses, sheep & goats followed by return to oestrus and normal ovulation. Cloprostenol also has direct stimulating effect on uterine smooth muscle.

Role of CLOPROSTENOL SODIUM in Anoestrus :-

• It causes constriction of utero-ovarian blood vessels causing partial ischemia, starvation & death of luteal cells.
• CLOPROSTENOL SODIUM competes with LH for receptor site & prevents further progesterone production.
• It inactivates the adenyl cyclase system to inhibit progesterone secretion and inactivates lysosomal enzymes to cause morphological regression of corpus luteum.

 

COMPOSITION :-
Each ml contains:
Cloprostenol sodium          I.P.          263 mcg
(eqv. to 250 mcg Cloprostenol)

INDICATION :-

Cows & Buffaloes :

• Luteal Cysts
• Pyometra
• Chronic Endometritis
• Mummified foetus
• Termination of pathological pregnancy

 

Mares :

• Pseudopregnancy
• Lactational anoestrus
• Synchronization of oestrus

 

Sheep, Goat & Swine :

• Synchronization of estrous

 

Canine :

• Pyometra
• Termination of pregnancy from mismating.

 

DOSE & ROUTE OF ADMINISTRATION :-

By I.M Route Only.

PRESENTATION :-
Vial of 2 ml including Tray, Syringe & Mono-Carton.