XYLADOT contains Xylazine which is a sedative, anaesthetic and muscle relaxant in nature.
RUMINANTS are the most sensitive of the domestic animals to action of XYLADOT.
In cattle and buffaloes, dose that produce deep sedation and analgesia is one tenth of the dose required in horses, dogs, cats etc. Aged or sick bovines that have undergone severe physical exertion have found to respond more strongly to XYLADOT.
Xylazine Hydrochloride B. Vet.C.
(eqv. to Xylazine 20 mg) : 23.32 mg
Diagnostic procedures — examination of mouth and ears, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radio-graphic examinations of head and extremities.
Orthopedic procedures – such as application of casting materials and splints.
Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations.
To calm and facilitate restraint of fractious animals.
Major surgical procedures:
When used as a pre-anesthetic to general anesthesia.
When used in conjunction with local anesthetics
DOSE & ROUTE OF ADMINISTRATION:
By I.M route only.
DOSE LEVEL 1.:
Is given for following purpose –
Tranquil the animal while on pasture.
To get accustomed to new surroundings.
Artificial insemination, e.g. ferocious animal like Khillari, Kankrej, Tharparkar.
Prolapse of uterus.
Correction of torsion of uterus.
DOSE LEVEL 2.:
Minor Surgical operation of teats.
Obstruction of the oesophagus.
insertion of nose ring.
DOSE LEVEL 3.:
(Combined with Local Anesthesia)
Major Operation – dehorning.
DOSE LEVEL 4.:
For undomesticated animals for prolonged operations. Several hours of fasting is required.
5 – 10 ml / 100 kg body weight
(eqv. to 100 – 200 mg / 100 kg body weight)
PRECAUTION IN CATTLE, BUFFALO & HORSE :
The tympany that may occur in any ruminant should be relieved by placing the animal in sternal recumbency. To prevent the aspiration of saliva or food material, the head and neck should be lowered.
Animals should be fasted before the administration of the high doses. The drug should not be used during the last month of pregnancy in view of the possibility of the premature birth.
When the subsequent period of hypnosis is prolonged, the animal should be protected against chilling or over-exposure to direct sunlight.
Caution is required in pulmonary conditions. In accidental overdoses, artificial respiration and central analeptics should be used.
0.5 ml – 1.5 ml / 10 kg body weight
(equivalent to 10 – 30 mg / 10 kg body weight).
0.05 – 0.1 ml / 1 kg body weight
(equivalent to 1 – 2 mg / kg body weight)
FOR PAINFUL CONDITIONS – FOR DOG & CAT
Required dose of XYLADOT with atropine medication to reduce vagal activity. Barbiturate dose to be reduced to about 1/3 to 1/4.
CONTRAINDICATIONS IN DOG & CAT :
XYLADOT should not be used in obstruction of oesophagus, torsion of the stomach, hernia etc. Caution is required in pulmonary condition.
OTHER DOMESTIC SPECIES / ZOO & WILD ANIMALS:
Based on pharmacological properties, XYLADOT injection can be used in other domestic species, zoo & wild animals. It is usually injected by I.M route, the onset of action is within 3 – 5 minutes and is augmented upto 15 minutes post injection after which the animals are usually approached.
ELEPHANT DOSAGE :
WEIGHT SEDATION IMMOBILIZATION
180 Kg 1 ml 2 ml
200 kg 4 ml 6 ml
450 kg 6 ml 8 ml
Full Grown elephant normally weights 3500 kg and dose of XYLADOT should be 20 ml.
OTHER IMPORTANT NOTES / PRECAUTIONS / CONTRAINDICATIONS CONCERNING APPLICATION OF XYLADOT :
The depth of sedation can be impaired by noise or disturbances. The animals should be left alone until the full onset of action has been achieved. If injection goes in fatty or connective tissues the desired effect will be delayed due to slow absorption and may be faster elimination.
ALWAYS REFER THE DETAILS ON XYLADOT IN PACKING INSERT BEFORE USE.
Vial of 10 ml & 30 ml.